- Obama, Barack - Forty-fourth President of the United States
- Oglesby, Carl - American writer, author of Who Killed JFK?, past president of Students for a Democratic Society
- O'Hara, Maureen - Irish-born red-haired Hollywood actress, starred in The Quiet Man
- Olbermann, Keith - Host of the Countdown show on MSNBC
- Opitz, Edmund A. - 20th century American author, longtime contributor to the Foundation for Economic Education
- Oppenheimer, Franz - German sociologist and economist, author of The State
- O'Rourke, P.J. - Political satirist, author
- Orwell, George - British writer, author of 1984 and Animal Farm
- Otis, James - 18th century American colonial lawyer
- Otter, C.L. "Butch" - Governor of Idaho and former Congressman
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